Sage Karam ended his third Indianapolis 500 effort in the barriers after running wide while battling wheel-to-wheel with Townsend Bell at turn one as the two drivers vied for sixth position on track.
The Dreyer & Reinbold Racing driver clashed with the Andretti Autosport driver on lap 94, with the youngster unable to keep the car out of the wall.
Karam hit the wall hard on the exit of turn one, and then continued around the wall before coming to rest on the exit of turn two, with the right hand side of his #24 car damaged.
The Holmatro Safety Team were again quickly on the scene, and the young American, seeking to return full-time to the Verizon IndyCar Series after being dropped by the Chip Ganassi Racing stable at the end of 2015, was able to walk away from the scene of the crash apparently unscathed.
It was the second crash of the race, with Juan Pablo Montoya being the first to crash in his #2 Team Penske car on lap 64.