Casey Stoner - Photo Credit: MotoGP.com
Riders' Championship (After Round 12: Indianapolis)
| Pos | Rider | Nat | Bike | Team | Wins | Pts |
| 1 | Casey Stoner | AUS | Honda | Repsol Honda Team | 7 | 243 |
| 2 | Jorge Lorenzo | SPA | Yamaha | Yamaha Factory Racing | 2 | 199 |
| 3 | Andrea Dovizioso | ITA | Honda | Repsol Honda Team | 174 | |
| 4 | Dani Pedrosa | SPA | Honda | Repsol Honda Team | 2 | 130 |
| 5 | Ben Spies | USA | Yamaha | Yamaha Factory Racing | 1 | 125 |
| 6 | Valentino Rossi | ITA | Ducati | Ducati Team | 124 | |
| 7 | Nicky Hayden | USA | Ducati | Ducati Team | 105 | |
| 8 | Colin Edwards | USA | Yamaha | Monster Yamaha Tech 3 | 84 | |
| 9 | Marco Simoncelli | ITA | Honda | San Carlo Honda Gresini | 80 | |
| 10 | Hiroshi Aoyama | JAP | Honda | San Carlo Honda Gresini | 77 | |
| 11 | Hector Barbera | SPA | Ducati | Mapfre Aspar Team MotoGP | 62 | |
| 12 | Alvaro Bautista | SPA | Suzuki | Rizla Suzuki MotoGP | 49 | |
| 13 | Karel Abraham | CZE | Ducati | Cardion AB Motoracing | 46 | |
| 14 | Toni Elias | SPA | Honda | LCR Honda MotoGP | 46 | |
| 15 | Cal Crutchlow | GBR | Yamaha | Monster Yamaha Tech 3 | 39 | |
| 16 | Loris Capirossi | ITA | Ducati | Pramac Racing Team | 29 | |
| 17 | Randy de Puniet | FRA | Ducati | Pramac Racing Team | 27 | |
| 18 | John Hopkins | USA | Suzuki | Rizla Suzuki MotoGP | 6 | |
| 19 | Kousuke Akiyoshi | JAP | Honda | San Carlo Honda Gresini | 3 |
